麻豆社

Bill Dawson, Head of Biologics and Devices Manufacturing at GSK, has been appointed the new Chair of the Medicines Manufacturing Industry Partnership (MMIP), a body representing the voice of medicines manufacturing in the UK.

The MMIP is an Expert Group of the Life Sciences Council, the UK鈥檚 most senior life sciences governance body, and is jointly managed by the Association of the British Pharmaceutical Industry (ABPI), the BioIndustry Association (BIA) and the Office for Life Sciences (OLS). It aims to help make the UK an attractive place for industry investment in manufacturing, to boost UK exports, provide highly skilled jobs and contribute to the economy.

Bill is a senior leader with over 25 years鈥� experience in the vaccines, biopharma, pharmaceutical and clinical research (CRO) industries, and has seen for himself the opportunity that medicines manufacturing presents to the UK economy.

On his appointment, he highlighted the value of the UK鈥檚 medicines manufacturing sector and renewed the MMIP鈥檚 calls for the UK to be a world leader in this area.

Bill Dawson, new Chair of the MMIP said: 鈥淧harmaceutical manufacturing plays a vital role in supporting the health of millions of people and is already delivering more than 拢16 billion in value to the UK economy. And it can do even more.

鈥淲ith the right partnership and support, over the next ten years the medicines manufacturing sector could attract an extra 拢15 billion investment in UK manufacturing, create more opportunities to adopt innovative technologies and deliver thousands more jobs in the UK.

鈥淎s Chair of the Medicines Manufacturing Industry Partnership, I hope to help make the UK one of the best places in the world to make new medicines, in the most sustainable way.鈥� 听

Steve Bates OBE, Chief Executive of the UK BioIndustry Association said 鈥淭he UK has the expertise to produce the most advanced therapies in the world, like those based on mRNA and CRISPR, and year on year, our manufacturing capacity is increasing.听

鈥榃e鈥檝e got to keep up this momentum and with Bill at the helm I鈥檓 sure our sector鈥檚 ability to deliver jobs, economic growth, and life-changing medicines for patients, will continue to accelerate.鈥�

Richard Torbett, Chief Executive of the 麻豆社said 鈥淚 would like to welcome Bill to his new role. The potential for medicines manufacturing to drive economic growth and job creation in the UK is huge.

鈥淚 am confident that under Bill's leadership of the MMIP, and with the considerable expertise he brings, that we can drive further improvements to make the UK the destination of choice for innovative and sustainable medicines manufacturing."

The ABPI鈥檚 new shows the spread of manufacturing facilities across the nations of the UK. Of the UK鈥檚 total of 497 medicines manufacturing sites, 399 are in England, 58 are in Scotland, 29 in Wales and 11 in Northern Ireland.

The MMIP wants to make the UK a world-leader in advanced and sustainable medicines manufacturing. Last year the partnership set out a 10 year vision which included calls for: 听听

• Investing 拢1.1bn investment over four years to provide sustained, predictable and accessible innovation funding and incentives, comprising 拢200m for collaborative R&D grants and 拢900m over four years for medicines manufacturing capital grant funding to unlock 拢6bn of industry investment
• Driving growth through leadership in environmentally sustainable medicines manufacturing, by:
  • developing an internationally recognised standard for greenhouse gas emissions;
  • developing a technology and innovation roadmap for environmentally sustainable medicines manufacturing;
  • Investing in the national infrastructure needed to support medicines manufacturers and their supply chains to transition to net zero and deliver on sustainability goals.
• Driving growth by fostering a pro-innovation operating environment including through internationally competitive fiscal incentives, and the establishment of an effective investment 鈥榝ront door鈥�

Since setting out this vision 鈥� there has already been significant progress. Including:

• 拢520million of long-term funding committed to capital grants for life sciences manufacturing [2]
• The launch of a competition to establish a Medicines Manufacturing Skills Centre of Excellence
• Longer-term certainty on fiscal incentives with full-expensing being made permanent, and the establishment of a new merged-R&D tax credit regime
• 拢400million committed by industry as part of a first-of-its-kind Voluntary Scheme investment programme, of which around 20 per cent of which will go to manufacturing, including collaborative R&D and grand challenge programmes to support innovation in sustainable and net-zero medicines manufacturing [3]

The MMIP is committed to working with Government to drive the delivery of its shared 10-year vision and maximising the opportunities provided by these recent announcements. 听

Case studies of manufacturing investment in the UK

GSK and sustainable manufacturing

As part of GSK鈥檚 commitment to a net zero impact on climate, they have set a target to transition to 100% renewable electricity by 2025. In September 2021, they announced a major 拢50m investment at manufacturing sites in Scotland and the US to secure renewable power generation. This includes a twenty-year power purchase agreement to build, run and maintain a 28MW solar and wind turbine facility at GSK鈥檚 Irvine site. When fully operational, this project will reduce GSK鈥檚 carbon footprint by around 7,000 tonnes of carbon annually. GSK is also working on a solar farm project at its Barnard Castle Site which would generate up to 16MWp of power.

AstraZeneca

AstraZeneca has . This significant investment will enhance public health protection and pandemic preparedness.听听

The company intends to invest 拢450 million at their manufacturing site in Speke, Liverpool for the research, development, and manufacture of vaccines. AstraZeneca will also expand its presence at Europe鈥檚 largest life sciences cluster in Cambridge with 拢200 million in investment. The facility will house around 1,000 employees and will be adjacent to its 拢1.1 billion global R&D Discovery Centre (DISC), which already hosts 2,300 researchers and scientists.

Moderna

A between Moderna and the government will see the company make a significant investment in research, development, and manufacturing in the UK. The Moderna Innovation and Technology Centre (MITC) at the Harwell Campus in Oxfordshire will bring innovative mRNA vaccines to the UK public. The site will employ more than 150 people and have the capacity to manufacture up to 250 million doses per year from 2025, increasing onshore supplies of respiratory vaccines and bringing much-needed resilience to the UK鈥檚 vaccine capability.

Autolus: From spin out to a potential billion-dollar business

Autolus makes personalised cancer treatments known as CAR-T cell therapies. These are created by harvesting a patient鈥檚 own immune cells, modifying them, before returning them to the patient where they locate and destroy tumours. More recently Autolus has expanded its pipeline into autoimmune diseases where it sees a significant opportunity.听 Autolus, spun-out from UCL in 2014 and has received 拢7.2 million in funding from Innovate UK to help develop innovative manufacturing approaches.

US FDA accepted Autolus鈥� first filing for a Biologics License Application (BLA) for its lead CAR-T cell product, obecabtagene autoleucel (obe-cel) for the treatment of relapsed/refractory (r/r) adult B-cell Acute Lymphoblastic Leukemia (ALL), with an expected PDUFA date in November 2024 and the company is on track to submit a marketing authorization application (MAA) submission to the European Medicines Agency (EMA) during the first half of 2024. Autolus supplied its clinical trials with products manufactured at the Cell and Gene Therapy Catapult Manufacturing Innovation Centre in Stevenage and has now fully validated its own 70,000sq ft flagship commercial manufacturing facility which will provide capacity for approximately 2,000 batches per year with room for expansion. The company is preparing for a potential launch of obe-cel and successfully transitioning Autolus into a commercial stage company.听 听听

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