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Horizon scanning and system readiness commitments

including the development of a new UK PharmaScan platform and end-to-end pathway guide. Databases to monitor Local Formulary variation and increase the visibility of Patient Support Programmes will also be introduced in England.

NHS England will consult on two updates to the Commercial Framework for New Medicines

to support broader and more predictable use of commercial flexibilities.

The Commercial Framework sets out how companies can work with NHS England on medicines access and commercial arrangements and the industry is hoping for more flexibility to bring England into line with other countries.

A review of the budget impact test threshold (BIT)

with the intent to increase it from 拢20 million to 拢40 million within the first six months of the scheme. The BIT limits the cost impact of new technology on the NHS England budget within the first three years.

Two new innovative payment model pilots

to support access to Advance Therapy Medicinal Products (ATMPs).

ATMPs are revolutionary medicines that are based on genes, tissues or cells. They have the potential to dramatically improve patient lives by treating the root cause of diseases, and in some cases may even be curative.

However, they present challenges for health systems because they are so different from traditional medicines. They are often only used as a one-time treatment - resulting in a high upfront cost - and offer long-term benefits which are hard to evidence at launch.听 The new model pilots will explore innovative solutions to these challenges.

Measures to support the equitable adoption of clinically and cost-effective medicines

In England, these include enhancements to national and regional clinical leadership job descriptions to embed championing of NICE-recommended medicines, further development of data tools to track variation in uptake of NICE-recommended medicines, and a new patient support programme (PSP) database to increase the visibility and scale-up of use of such programmes.